ZNF683

Across TCGA cell cohorts, ZNF683 RNA expression is significantly associated with the go_rna of many other GO terms, with 249 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ZNF683-associated GO terms across cancer lineages are Regulation of cell fate commitment, Negative regulation of MAP kinase activity, and Negative regulation of smooth muscle cell chemotaxis. Each is linked with ZNF683 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF683-to-partner and partner-to-ZNF683 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of cell fate commitment grouped by ZNF683-low versus ZNF683-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF683→partner) and Y-score (partner→ZNF683) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Regulation of cell fate commitment →	+0.064	+0.829	.002	.007	3	3
BLOOD_Leukemia	Negative regulation of MAP kinase activity →	+0.059	+0.866	<.001	.004	3	3
CNS	Negative regulation of smooth muscle cell chemotaxis →	+0.107	+0.020	.002	.003	3	3
LUNG_NSCLC_LUAD	Positive regulation of amyloid precursor protein catabolic process →	-0.075	-0.008	.001	.004	3	2
BLOOD_Leukemia	Positive regulation of neutrophil migration →	-0.084	-0.627	<.001	.004	3	2
BLOOD_Leukemia	U2-type prespliceosome assembly →	+0.033	+0.572	.009	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 249 associations by consensus.

Regulation of cell fate commitment by ZNF683 expression — BLOOD_Leukemia

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