ZNF683

Across TCGA cell cohorts, ZNF683 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible ZNF683-associated genes across cancer lineages are TAAR8, OR56B1, and MRGPRG. Each is linked with ZNF683 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF683-to-partner and partner-to-ZNF683 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TAAR8 grouped by ZNF683-low versus ZNF683-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF683→partner) and Y-score (partner→ZNF683) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	TAAR8 →	+0.017	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR56B1 →	+0.028	+5.472	.003	<.001	3	1
LUNG_NSCLC_LUAD	MRGPRG →	+0.026	+4.544	<.001	.003	3	1
LUNG_NSCLC_LUAD	OR4C12 →	+0.017	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	OTC →	+0.022	+4.371	<.001	.005	3	1
LUNG_SCLC	OR4D6 →	+0.017	+4.643	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

TAAR8 by ZNF683 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →