Across TCGA patient cohorts, ZNF682 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF682-associated genes across cancer lineages are Notch1, MEK1, and BRD4. Each is linked with ZNF682 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF682-to-partner and partner-to-ZNF682 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF682→partner) and Y-score (partner→ZNF682) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.182	+2.710	<.001	.003	3	3
UCEC	MEK1 →	+0.397	+2.906	.003	.001	3	2
UCEC	BRD4 →	+0.216	+3.169	.040	.018	3	2
UCEC	Caspase-7-cleavedD198 →	+0.682	+2.169	.002	.003	3	2
UCEC	C-Raf →	+0.127	+1.765	.018	.014	3	2
SKCM	GATA3 →	+0.210	+3.000	.022	.035	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

Exploration

ZNF682 survival (RNA) · tumor vs normal (RNA) · all ZNF682 data types