ZNF678

Across TCGA patient cohorts, ZNF678 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF678-associated genes across cancer lineages are FASN, PKC-b-II_pS660, and Shc_pY317. Each is linked with ZNF678 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF678-to-partner and partner-to-ZNF678 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by ZNF678-low versus ZNF678-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF678→partner) and Y-score (partner→ZNF678) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	FASN →	+0.748	+3.008	<.001	.019	3	2
COAD	PKC-b-II_pS660 →	-0.488	-2.991	.007	.036	3	2
COAD	Shc_pY317 →	-0.198	-2.991	.022	.036	3	2
COAD	ATM →	-0.629	-2.991	.001	.036	3	2
COAD	C-Raf →	+0.207	+3.008	.006	.019	3	2
UCEC	INPP4B →	-0.262	-2.700	.024	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

FASN by ZNF678 expression — COAD

Explore this box plot interactively →