ZNF678

Across TCGA cell cohorts, ZNF678 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,153 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ZNF678-associated GO terms across cancer lineages are Epigenetic regulation of gene expression, Nuclear pore complex assembly, and Nuclear pore organization. Each is linked with ZNF678 in more than 15 cancer types. Because this analysis shows association rather than direction, both ZNF678-to-partner and partner-to-ZNF678 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Epigenetic regulation of gene expression grouped by ZNF678-low versus ZNF678-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF678→partner) and Y-score (partner→ZNF678) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Epigenetic regulation of gene expression →	+0.094	+1.228	.001	.008	3	16
BONE	Nuclear pore complex assembly →	+0.213	+1.562	<.001	<.001	3	16
BONE	Nuclear pore organization →	+0.145	+0.916	<.001	<.001	3	16
BONE	Regulation of double-strand break repair via homologous recombination →	+0.124	+1.513	.001	<.001	3	16
LUNG_SCLC	DNA-templated DNA replication maintenance of fidelity →	+0.099	+0.958	<.001	<.001	3	16
PANCREAS	Constitutive heterochromatin formation →	+0.104	+0.654	<.001	.003	2	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,153 associations by consensus.

Epigenetic regulation of gene expression by ZNF678 expression — BONE

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