Across TCGA patient cohorts, ZNF677 mutation is significantly associated with the RNA expression of many other genes, with 2,453 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF677-associated genes across cancer lineages are ASS1P8, THRB, and MVD. Each is linked with ZNF677 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF677-to-partner and partner-to-ZNF677 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF677→partner) and Y-score (partner→ZNF677) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ASS1P8 →	+0.018	+3.039	<.001	.006	3	3
UCEC	THRB →	-0.563	-1.853	.009	.002	3	3
UCEC	MVD →	+0.793	+2.617	<.001	<.001	3	3
UCEC	CHAF1A →	+0.786	+3.080	<.001	<.001	3	3
UCEC	THOP1 →	+0.724	+2.212	<.001	<.001	3	3
UCEC	DDX23 →	+0.510	+2.662	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,453 associations by consensus.

Exploration

ZNF677 survival (RNA) · tumor vs normal (RNA) · all ZNF677 data types