Across TCGA cell cohorts, ZNF677 mutation is significantly associated with the mutation status of many other genes, with 4,318 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF677-associated genes across cancer lineages are KIF18B, PCDHA4, and CFB. Each is linked with ZNF677 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF677-to-partner and partner-to-ZNF677 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF677→partner) and Y-score (partner→ZNF677) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	KIF18B →	+5.614	+5.044	.003	.003	1	3
LARGE_INTESTINE	PCDHA4 →	+2.514	+3.058	.002	.002	1	3
LARGE_INTESTINE	CFB →	+2.584	+3.635	<.001	<.001	1	3
LUNG_NSCLC_LUAD	COQ8A →	+4.339	+4.339	.009	.009	1	3
CNS	FGFR1 →	+5.614	+5.044	.003	.003	1	3
CNS	ITGAM →	+5.614	+5.044	.003	.003	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,318 associations by consensus.

Exploration

ZNF677 survival (RNA) · tumor vs normal (RNA) · all ZNF677 data types