ZNF674-AS1

Across TCGA pan-cancer cohorts, ZNF674-AS1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated ZNF674-AS1 data layer.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher ZNF674-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ZNF674-AS1 expression acts as an unfavorable survival marker, although some lineages such as BLCA and PAAD show a favorable association.

COAD, ACC, and UVM are the cancer types where ZNF674-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Tertile	II,III,IV	0.562	0.731	.002	78	view →
ACC	DFS	Tertile	All	0.258	0.730	<.001	68	view →
UVM	DFS	Tertile	III,IV	0.206	0.925	<.001	60	view →
KIRC	DFS	Quartile	II,III,IV	0.389	0.649	.009	57	view →
BLCA	DFS	Quartile	IV	0.526	0.267	.001	51	view →
KIRP	DFS	Quartile	III,IV	0.107	0.659	.001	40	view →
LGG	OS	Tertile	All	0.726	0.862	<.001	39	view →
PAAD	DFS	Median	All	0.529	0.243	.001	37	view →
MESO	OS	Median	All	0.433	0.662	.001	34	view →
LUAD	OS	Quartile	All	0.414	0.261	.003	30	view →
LIHC	OS	Median	All	0.708	0.840	<.001	28	view →
LUSC	OS	Median	All	0.822	0.729	<.001	22	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

ZNF674-AS1–COAD (DFS)

Open the COAD breakdown →