ZNF672

Across TCGA patient cohorts, ZNF672 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF672-associated genes across cancer lineages are eIF4E, ATM, and MSH6. Each is linked with ZNF672 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF672-to-partner and partner-to-ZNF672 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by ZNF672-low versus ZNF672-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF672→partner) and Y-score (partner→ZNF672) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.223	+2.263	.001	<.001	3	2
COAD	ATM →	-0.410	-2.313	.019	.035	3	2
UCEC	MSH6 →	-0.246	-1.874	.023	.049	3	2
UCEC	Rad50 →	-0.192	-2.102	.016	.016	3	2
UCEC	4E-BP1 →	+0.236	+2.936	.008	<.001	3	2
COAD	Acetyl-a-Tubulin-Lys40 →	-0.465	-3.450	.034	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

eIF4E by ZNF672 expression — UCEC

Explore this box plot interactively →