ZNF671

Across TCGA patient cohorts, ZNF671 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF671-associated genes across cancer lineages are Shc_pY317, 4E-BP1, and mTOR_pS2448. Each is linked with ZNF671 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF671-to-partner and partner-to-ZNF671 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Shc_pY317 grouped by ZNF671-low versus ZNF671-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF671→partner) and Y-score (partner→ZNF671) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Shc_pY317 →	-0.142	-2.115	.031	.019	3	2
UCEC	4E-BP1 →	+0.313	+2.999	.008	.035	3	2
UCEC	mTOR_pS2448 →	-0.176	-3.308	.006	.009	3	1
UCEC	mTOR →	-0.207	-2.115	.003	.019	3	1
UCEC	Notch1 →	+0.184	+3.469	.002	.002	3	1
UCEC	p27_pT198 →	+0.137	+2.321	.003	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Shc_pY317 by ZNF671 expression — UCEC

Explore this box plot interactively →