ZNF670

Across TCGA patient cohorts, ZNF670 mutation is significantly associated with the RNA expression of many other genes, with 2,037 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF670-associated genes across cancer lineages are SLC35C1, SHMT2, and PGP. Each is linked with ZNF670 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF670-to-partner and partner-to-ZNF670 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC35C1 grouped by ZNF670-low versus ZNF670-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF670→partner) and Y-score (partner→ZNF670) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SLC35C1 →	+0.395	+2.617	.004	.005	3	2
UCEC	SHMT2 →	+0.728	+3.108	<.001	<.001	3	2
UCEC	PGP →	+0.466	+2.850	.001	.001	3	2
UCEC	BRI3BP →	+0.704	+2.470	<.001	<.001	3	2
UCEC	FAF1 →	+0.372	+3.108	<.001	<.001	3	2
UCEC	ACTBP7 →	+0.370	+2.680	.003	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,037 associations by consensus.

SLC35C1 by ZNF670 expression — UCEC

Explore this box plot interactively →