ZNF670-ZNF695

Across TCGA pan-cancer cohorts, ZNF670-ZNF695 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated ZNF670-ZNF695 data layer compared with 1 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher ZNF670-ZNF695 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ZNF670-ZNF695 expression acts as an unfavorable survival marker, although some lineages such as READ and KIRC show a favorable association.

KICH, ACC, and MESO are the cancer types where ZNF670-ZNF695 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	OS	Quartile	All	0.499	1.000	.003	75	view →
ACC	OS	Tertile	All	0.343	0.786	<.001	56	view →
MESO	DFS	Median	II,III,IV	0.203	0.698	<.001	52	view →
KIRP	DFS	Quartile	All	0.544	0.860	<.001	45	view →
UCEC	OS	Median	All	0.829	0.915	<.001	44	view →
SARC	DFS	Tertile	All	0.377	0.677	<.001	29	view →
CESC	DFS	Tertile	All	0.417	0.617	.002	24	view →
UVM	DFS	Median	III,IV	0.323	0.867	.018	24	view →
READ	OS	Tertile	II,III,IV	1.000	0.494	.021	23	view →
LIHC	DFS	Tertile	All	0.433	0.596	.003	23	view →
HNSC	OS	Median	III,IV	0.208	0.414	.006	14	view →
ESCA	DFS	Median	All	0.458	0.609	.018	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

ZNF670-ZNF695–KICH (OS)

Open the KICH breakdown →