Across TCGA patient cohorts, ZNF669 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF669-associated genes across cancer lineages are ERK2, MEK1, and Notch1. Each is linked with ZNF669 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF669-to-partner and partner-to-ZNF669 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF669→partner) and Y-score (partner→ZNF669) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.204	+2.999	.015	.035	3	1
UCEC	MEK1 →	+0.496	+2.584	.001	.010	3	1
UCEC	Notch1 →	+0.166	+3.469	.007	.002	3	1
UCEC	PDCD4 →	-0.606	-2.575	.003	.010	3	1
UCEC	Rad50 →	-0.257	-2.115	.015	.019	3	1
UCEC	Annexin-1 →	+0.466	+3.019	.042	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Exploration

ZNF669 survival (RNA) · tumor vs normal (RNA) · all ZNF669 data types