ZNF668

Across TCGA pan-cancer cohorts, ZNF668 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ZNF668 data layer compared with 24 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ZNF668 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated ZNF668 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

HNSC, LUAD, and GBM are the cancer types where ZNF668 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	II,III,IV	1.000	0.955	.027	10	view →
LUAD	DFS	Quartile	III,IV	1.000	0.302	.017	3	view →
GBM	OS	Median	All	0.537	0.253	.011	3	view →
LSCC	DFS	Tertile	II,III,IV	0.797	0.434	.039	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

ZNF668–HNSC (OS)

Open the HNSC breakdown →