ZNF668

Across TCGA patient cohorts, ZNF668 mutation is significantly associated with the RNA expression of many other genes, with 2,487 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF668-associated genes across cancer lineages are PSMC3IP, TSPY26P, and ITGAE. Each is linked with ZNF668 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF668-to-partner and partner-to-ZNF668 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PSMC3IP grouped by ZNF668-low versus ZNF668-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF668→partner) and Y-score (partner→ZNF668) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PSMC3IP →	+0.553	+2.747	.001	<.001	3	3
UCEC	TSPY26P →	-0.823	-2.321	<.001	.005	3	3
UCEC	ITGAE →	+0.616	+3.392	<.001	<.001	3	3
UCEC	RNU1-68P →	+0.063	+3.140	<.001	.004	3	2
HNSC	RNU6-598P →	+0.321	+4.124	<.001	.002	3	2
HNSC	MIR181B2 →	+0.517	+3.428	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,487 associations by consensus.

PSMC3IP by ZNF668 expression — UCEC

Explore this box plot interactively →