ZNF668

Across TCGA patient cohorts, ZNF668 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF668-associated genes across cancer lineages are GAPDH, MEK1, and Annexin-1. Each is linked with ZNF668 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF668-to-partner and partner-to-ZNF668 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by ZNF668-low versus ZNF668-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF668→partner) and Y-score (partner→ZNF668) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	GAPDH →	+0.661	+2.815	.017	.036	3	3
UCEC	MEK1 →	+0.412	+2.115	.003	.017	3	2
UCEC	Annexin-1 →	+0.702	+3.720	<.001	<.001	3	2
UCEC	STAT3_pY705 →	-0.212	-1.678	.034	.023	3	2
UCEC	VHL →	-0.807	-2.700	.001	.006	3	2
UCEC	ATM →	-0.414	-2.087	.017	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

GAPDH by ZNF668 expression — COAD

Explore this box plot interactively →