ZNF668

Across TCGA cell cohorts, ZNF668 mutation is significantly associated with the RNA expression of many other genes, with 1,220 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF668-associated genes across cancer lineages are OR4K1, C18orf63, and LRIG3. Each is linked with ZNF668 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF668-to-partner and partner-to-ZNF668 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4K1 grouped by ZNF668-low versus ZNF668-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF668→partner) and Y-score (partner→ZNF668) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	OR4K1 →	+0.015	+4.977	<.001	.002	3	2
SOFT_TISSUE	C18orf63 →	+0.004	+4.369	<.001	.008	3	2
BLOOD_Leukemia	LRIG3 →	+0.803	+3.392	.004	.005	3	2
CNS	CDCP2 →	+0.042	+4.273	<.001	.002	3	2
BLOOD_Leukemia	NKX2-6 →	+0.215	+3.201	<.001	.005	3	2
LARGE_INTESTINE	CEP76 →	+0.673	+2.158	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,220 associations by consensus.

OR4K1 by ZNF668 expression — SOFT_TISSUE

Explore this box plot interactively →