Across TCGA patient cohorts, ZNF665 mutation is significantly associated with the RNA expression of many other genes, with 3,882 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF665-associated genes across cancer lineages are TIMM44, CCNB2, and FEN1. Each is linked with ZNF665 in more than 4 cancer types. Because this analysis shows association rather than direction, both ZNF665-to-partner and partner-to-ZNF665 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF665→partner) and Y-score (partner→ZNF665) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TIMM44 →	+0.340	+2.118	<.001	<.001	3	5
UCEC	CCNB2 →	+0.636	+2.279	<.001	<.001	3	4
UCEC	FEN1 →	+0.449	+1.999	.006	.002	3	4
SKCM	CKAP2L →	+0.687	+1.771	.002	.008	3	4
UCEC	SLC25A33 →	+0.584	+1.765	<.001	<.001	3	4
SKCM	PPP2R2D →	+0.378	+2.201	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,882 associations by consensus.

Exploration

ZNF665 survival (RNA) · tumor vs normal (RNA) · all ZNF665 data types