ZNF66

Across TCGA pan-cancer cohorts, ZNF66 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated ZNF66 data layer compared with 21 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher ZNF66 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ZNF66 expression acts as an unfavorable survival marker.

LUSC, BLCA, and LIHC are the cancer types where ZNF66 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Median	All	0.528	0.776	<.001	10	view →
BLCA	OS	Median	III,IV	0.069	0.582	<.001	6	view →
LIHC	OS	Median	All	0.167	0.688	.035	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

ZNF66–LUSC (OS)

Open the LUSC breakdown →