ZNF66

Across TCGA cell cohorts, ZNF66 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,201 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ZNF66-associated GO terms across cancer lineages are Regulation of double-strand break repair via homologous recombination, Regulation of double-strand break repair, and Positive regulation of double-strand break repair. Each is linked with ZNF66 in more than 10 cancer types. Because this analysis shows association rather than direction, both ZNF66-to-partner and partner-to-ZNF66 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of double-strand break repair via homologous recombination grouped by ZNF66-low versus ZNF66-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF66→partner) and Y-score (partner→ZNF66) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Regulation of double-strand break repair via homologous recombination →	+0.102	+1.198	<.001	<.001	3	11
SOFT_TISSUE	Regulation of double-strand break repair →	+0.077	+1.140	<.001	<.001	3	10
SOFT_TISSUE	Positive regulation of double-strand break repair →	+0.079	+1.173	<.001	<.001	3	10
SOFT_TISSUE	Positive regulation of DNA metabolic process →	+0.065	+1.214	<.001	<.001	3	10
BLOOD_Lymphoma	Regulation of transcription initiation by RNA polymerase II →	+0.065	+1.413	<.001	<.001	3	10
STOMACH	Regulation of hematopoietic stem cell differentiation →	+0.115	+1.021	.001	.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,201 associations by consensus.

Regulation of double-strand break repair via homologous recombination by ZNF66 expression — SOFT_TISSUE

Explore this box plot interactively →