Across TCGA pan-cancer cohorts, ZNF655 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ZNF655 data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher ZNF655 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated ZNF655 expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

PDAC, LUAD, and LSCC are the cancer types where ZNF655 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Tertile	III,IV	0.225	0.844	.006	19	view →
LUAD	DFS	Quartile	All	0.992	0.786	.003	16	view →
LSCC	DFS	Tertile	All	0.751	0.912	.036	2	view →
HNSC	OS	Median	III,IV	0.562	0.787	.041	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: ZNF655 tumor-vs-normal RNA expression · all ZNF655 data types