ZNF654

Across TCGA pan-cancer cohorts, ZNF654 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ZNF654 data layer compared with 26 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher ZNF654 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ZNF654 expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

PDAC, HNSC, and LUAD are the cancer types where ZNF654 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	All	0.805	1.000	.013	20	view →
HNSC	DFS	Quartile	III,IV	0.814	1.000	.038	13	view →
LUAD	DFS	Tertile	III,IV	0.778	0.354	.028	9	view →
GBM	OS	Median	All	0.428	0.613	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

ZNF654–PDAC (DFS)

Open the PDAC breakdown →