ZNF654

Across TCGA patient cohorts, ZNF654 RNA expression is significantly associated with the protein abundance of many other proteins, with 10,687 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible ZNF654-associated proteins across cancer lineages are DDX28, ALG5, and LETMD1. Each is linked with ZNF654 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZNF654-to-partner and partner-to-ZNF654 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ZNF654 versus DDX28 in OV, with a Pearson correlation of -0.41.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF654→partner) and Y-score (partner→ZNF654) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	DDX28 →	-0.452	-0.505	<.001	.002	3	4
PDAC	ALG5 →	-0.377	-0.376	<.001	<.001	3	4
BRCA	LETMD1 →	-0.455	-0.585	<.001	.001	3	4
BRCA	PAFAH1B3 →	+0.475	+0.617	<.001	<.001	3	4
UCEC	OXSR1 →	+0.275	+0.470	<.001	<.001	3	4
PDAC	CD5L →	+0.600	+0.289	.002	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,687 associations by consensus.

ZNF654 vs DDX28 — OV

Explore this scatter interactively →