ZNF654

Across TCGA patient cohorts, ZNF654 mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF654-associated genes across cancer lineages are FASN, VHL, and ASNS. Each is linked with ZNF654 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF654-to-partner and partner-to-ZNF654 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by ZNF654-low versus ZNF654-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF654→partner) and Y-score (partner→ZNF654) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.322	+2.415	.010	.003	3	2
UCEC	VHL →	-0.680	-1.736	.001	.006	3	2
UCEC	ASNS →	+0.518	+2.321	<.001	<.001	3	2
UCEC	ATM →	-0.314	-1.523	.030	.008	3	2
UCEC	14-3-3_beta →	-0.106	-2.060	<.001	.004	3	1
UCEC	EGFR_pY1068 →	-0.225	-2.087	.004	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

FASN by ZNF654 expression — UCEC

Explore this box plot interactively →