ZNF654

Across TCGA cell cohorts, ZNF654 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,990 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ZNF654-associated GO terms across cancer lineages are Negative regulation of chromosome condensation, Positive regulation of pinocytosis, and Endosomal transport. Each is linked with ZNF654 in more than 11 cancer types. Because this analysis shows association rather than direction, both ZNF654-to-partner and partner-to-ZNF654 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of chromosome condensation grouped by ZNF654-low versus ZNF654-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF654→partner) and Y-score (partner→ZNF654) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Negative regulation of chromosome condensation →	+0.099	+0.607	.009	.003	3	12
BLOOD_Leukemia	Positive regulation of pinocytosis →	+0.117	+0.636	<.001	<.001	3	12
SKIN	Endosomal transport →	+0.066	+0.811	<.001	.001	3	11
LUNG_SCLC	Macroautophagy →	+0.044	+0.511	.005	.006	3	11
LIVER	Positive regulation of endoplasmic reticulum tubular network organization →	+0.105	+0.975	.002	<.001	3	11
BLOOD_Leukemia	Error-prone translesion synthesis →	+0.094	+0.635	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,990 associations by consensus.

Negative regulation of chromosome condensation by ZNF654 expression — BLOOD_Lymphoma

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