ZNF654

Across TCGA cell cohorts, ZNF654 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ZNF654-associated genes across cancer lineages are ZNF831, VSIG4, and BPIFA1. Each is linked with ZNF654 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF654-to-partner and partner-to-ZNF654 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF831 grouped by ZNF654-low versus ZNF654-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF654→partner) and Y-score (partner→ZNF654) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ZNF831 →	+0.010	+2.688	<.001	.008	3	1
LARGE_INTESTINE	VSIG4 →	+0.019	+2.791	.002	.005	3	1
LARGE_INTESTINE	BPIFA1 →	+0.101	+2.688	.006	.008	3	1
LUNG_NSCLC_LUAD	FAM71B →	+0.003	+4.078	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR5M10 →	+0.011	+4.078	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR8K3 →	+0.004	+4.681	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

ZNF831 by ZNF654 expression — LARGE_INTESTINE

Explore this box plot interactively →