ZNF649

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, ZNF649 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF649-associated genes across cancer lineages are MEK1, p90 RSK, and PDCD4. Each is linked with ZNF649 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF649-to-partner and partner-to-ZNF649 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF649→partner) and Y-score (partner→ZNF649) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECMEK1 →+0.388+1.836<.001.00132
UCECp90 RSK →+0.132+1.424.028.02732
UCECPDCD4 →-0.311-1.353.036.01532
UCECCD49b →-0.230-2.565.010.00132
UCECC-Raf →+0.125+1.353.005.01532
UCEC14-3-3_beta →-0.068-1.124.030.04131
Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

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