Across TCGA cell cohorts, ZNF649 mutation is significantly associated with the RNA expression of many other genes, with 79 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ZNF649-associated genes across cancer lineages are OR52L1, ACTL7A, and USP17L7. Each is linked with ZNF649 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF649-to-partner and partner-to-ZNF649 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF649→partner) and Y-score (partner→ZNF649) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR52L1 →	+0.042	+3.362	.009	.007	3	2
BLOOD_Leukemia	ACTL7A →	+0.012	+2.481	<.001	.008	3	2
LARGE_INTESTINE	USP17L7 →	+0.074	+3.691	<.001	.009	3	2
BLOOD_Leukemia	UBE2S →	+0.911	+3.351	.001	.003	3	1
BLOOD_Leukemia	NPPB →	+0.073	+3.078	<.001	.001	3	1
LUNG_NSCLC_LUAD	ADGB →	+0.055	+3.882	.006	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 79 associations by consensus.

Exploration

ZNF649 survival (RNA) · tumor vs normal (RNA) · all ZNF649 data types