ZNF648

Across TCGA patient cohorts, ZNF648 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,058 significant associations in total. STAD shows the largest number of these associations.

The most reproducible ZNF648-associated GO terms across cancer lineages are Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, Positive regulation of chromosome organization, and DNA-templated transcription elongation. Each is linked with ZNF648 in more than 20 cancer types. Because this analysis shows association rather than direction, both ZNF648-to-partner and partner-to-ZNF648 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay grouped by ZNF648-low versus ZNF648-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF648→partner) and Y-score (partner→ZNF648) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay →	+0.067	+0.239	.001	<.001	3	21
ESCA	Positive regulation of chromosome organization →	+0.071	+0.239	.003	.001	3	20
STAD	DNA-templated transcription elongation →	+0.055	+0.121	<.001	<.001	3	20
STAD	Golgi organization →	+0.051	+0.113	<.001	<.001	3	20
STAD	Positive regulation of DNA metabolic process →	+0.046	+0.128	<.001	<.001	3	20
ESCA	Smoothened signaling pathway →	+0.051	+0.210	<.001	<.001	3	20

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,058 associations by consensus.

Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay by ZNF648 expression — ESCA

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