ZNF648

Across TCGA patient cohorts, ZNF648 mutation is significantly associated with the RNA expression of many other genes, with 3,406 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF648-associated genes across cancer lineages are SLC25A19, TACC3, and CRK. Each is linked with ZNF648 in more than 4 cancer types. Because this analysis shows association rather than direction, both ZNF648-to-partner and partner-to-ZNF648 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC25A19 grouped by ZNF648-low versus ZNF648-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF648→partner) and Y-score (partner→ZNF648) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SLC25A19 →	+0.378	+2.019	.001	.001	3	4
LUAD	TACC3 →	+0.775	+3.468	<.001	.002	3	4
COAD	CRK →	+0.509	+3.199	<.001	.009	3	4
UCEC	HASPIN →	+0.628	+1.934	<.001	.002	3	4
UCEC	OIP5 →	+0.786	+2.506	<.001	<.001	3	4
STAD	NCAPG →	+1.037	+3.484	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,406 associations by consensus.

SLC25A19 by ZNF648 expression — SKCM

Explore this box plot interactively →