ZNF648

Across TCGA patient cohorts, ZNF648 mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF648-associated genes across cancer lineages are Cyclin-B1, Di-Ras3, and C-Raf. Each is linked with ZNF648 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZNF648-to-partner and partner-to-ZNF648 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by ZNF648-low versus ZNF648-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF648→partner) and Y-score (partner→ZNF648) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Cyclin-B1 →	+0.675	+3.008	.016	.019	3	4
UCEC	Di-Ras3 →	-0.147	-1.440	.004	.024	3	3
UCEC	C-Raf →	+0.130	+2.222	.008	.010	3	3
COAD	ASNS →	+0.902	+3.008	<.001	.019	3	2
UCEC	14-3-3_beta →	-0.091	-2.432	.009	.018	3	2
UCEC	eEF2 →	+0.355	+2.584	.004	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

Cyclin-B1 by ZNF648 expression — COAD

Explore this box plot interactively →