ZNF646

Across TCGA pan-cancer cohorts, ZNF646 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated ZNF646 data layer compared with 25 for mass-spec protein and 11 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ZNF646 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated ZNF646 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

HNSC, UCEC, and CCRCC are the cancer types where ZNF646 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	1.000	0.914	.002	15	view →
UCEC	OS	Median	III,IV	1.000	0.140	.024	12	view →
CCRCC	OS	Tertile	III,IV	0.980	0.374	.013	8	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

ZNF646–HNSC (DFS)

Open the HNSC breakdown →