ZNF644

Across TCGA pan-cancer cohorts, ZNF644 mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of ZNF644’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where ZNF644 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types ZNF644 is over-expressed in tumor, although a few such as PDAC show the opposite, repressed pattern.

LSCC, LUAD, and PDAC are the cancer types where ZNF644 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF644 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Female	All	+0.245	<.001	6	view →
LUAD	All	II,III,IV	+0.181	<.001	6	view →
PDAC	Female	III,IV	−0.163	.008	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

ZNF644–LSCC

Open the LSCC breakdown →