ZNF641

Across TCGA pan-cancer cohorts, ZNF641 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of ZNF641’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where ZNF641 RNA is repressed in tumor relative to normal tissue. In most cancer types ZNF641 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, THCA, and LIHC are the cancer types where ZNF641 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF641 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	All	−1.036	<.001	10	view →
THCA	All	II,III,IV	−0.475	<.001	8	view →
LIHC	Female	II,III,IV	+0.733	<.001	7	view →
HNSC	All	III,IV	+0.500	.002	6	view →
BLCA	All	IV	−0.941	.006	5	view →
CHOL	All	All	+1.501	<.001	3	view →
UCEC	All	All	−0.587	<.001	2	view →
BRCA	Female	All	−0.144	.018	2	view →
LUAD	Female	II,III,IV	−0.424	.031	1	view →
STAD	All	II,III,IV	+0.419	.048	1	view →
KIRP	Male	All	−0.335	.023	1	view →
KIRC	Female	All	+0.303	.043	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

ZNF641–KICH

Open the KICH breakdown →