ZNF639

Across TCGA pan-cancer cohorts, ZNF639 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ZNF639 data layer compared with 22 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ZNF639 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated ZNF639 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LUAD show a favorable association.

HNSC, CCRCC, and PDAC are the cancer types where ZNF639 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	II,III,IV	0.772	0.923	.012	28	view →
CCRCC	OS	Quartile	III,IV	0.916	0.219	.003	17	view →
PDAC	DFS	Median	All	0.213	0.586	<.001	12	view →
LUAD	DFS	Median	III,IV	0.688	0.434	.020	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

ZNF639–HNSC (OS)

Open the HNSC breakdown →