ZNF639

Across TCGA patient cohorts, ZNF639 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF639-associated genes across cancer lineages are IGFBP2, MEK1, and Myosin-IIa_pS1943. Each is linked with ZNF639 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF639-to-partner and partner-to-ZNF639 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGFBP2 grouped by ZNF639-low versus ZNF639-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF639→partner) and Y-score (partner→ZNF639) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IGFBP2 →	-1.058	-2.222	<.001	.011	3	1
UCEC	MEK1 →	+0.370	+3.321	.017	.010	3	1
UCEC	Myosin-IIa_pS1943 →	+0.180	+1.713	.039	.027	3	1
UCEC	PDK1_pS241 →	+0.168	+3.459	.020	.005	3	1
UCEC	Shc_pY317 →	-0.140	-2.321	.030	.034	3	1
UCEC	VHL →	-0.699	-1.700	.015	.044	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

IGFBP2 by ZNF639 expression — UCEC

Explore this box plot interactively →