ZNF638

Across TCGA pan-cancer cohorts, ZNF638 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated ZNF638 data layer compared with 29 for mass-spec protein and 10 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ZNF638 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ZNF638 expression acts as an unfavorable survival marker, although some lineages such as PDAC and GBM show a favorable association.

HNSC, PDAC, and GBM are the cancer types where ZNF638 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.264	0.886	.002	45	view →
PDAC	OS	Median	IV	0.951	0.381	.006	13	view →
GBM	DFS	Tertile	All	0.446	0.289	.010	9	view →
LUAD	OS	Tertile	III,IV	0.731	0.247	.036	4	view →
CCRCC	OS	Median	III,IV	0.615	0.837	.025	3	view →
LSCC	OS	Median	II,III,IV	0.810	1.000	.035	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

ZNF638–HNSC (DFS)

Open the HNSC breakdown →