ZNF638

Across TCGA patient cohorts, ZNF638 mutation is significantly associated with the RNA expression of many other genes, with 4,933 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF638-associated genes across cancer lineages are DEPDC1, RASSF1, and RFC5. Each is linked with ZNF638 in more than 4 cancer types. Because this analysis shows association rather than direction, both ZNF638-to-partner and partner-to-ZNF638 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEPDC1 grouped by ZNF638-low versus ZNF638-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF638→partner) and Y-score (partner→ZNF638) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	DEPDC1 →	+0.721	+3.207	.003	.009	3	5
SKCM	RASSF1 →	+0.443	+2.739	.003	.003	3	4
UCEC	RFC5 →	+0.446	+2.081	<.001	<.001	3	4
UCEC	KIF20A →	+0.554	+2.643	<.001	<.001	3	4
COAD	GOT1 →	+0.571	+3.348	.001	.005	3	4
UCEC	MRPS36 →	+0.414	+1.512	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,933 associations by consensus.

DEPDC1 by ZNF638 expression — SKCM

Explore this box plot interactively →