ZNF638

Across TCGA patient cohorts, ZNF638 mutation is significantly associated with the total protein of many other genes, with 64 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF638-associated genes across cancer lineages are TFRC, PAI-1, and NF2. Each is linked with ZNF638 in more than 4 cancer types. Because this analysis shows association rather than direction, both ZNF638-to-partner and partner-to-ZNF638 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by ZNF638-low versus ZNF638-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF638→partner) and Y-score (partner→ZNF638) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	TFRC →	+0.867	+3.169	.004	.019	2	5
LUSC	PAI-1 →	+0.949	+3.009	.005	.019	3	4
STAD	NF2 →	+0.165	+3.000	.044	.034	3	3
COAD	ATM →	-0.682	-3.000	<.001	.035	3	3
STAD	CDK1 →	+0.461	+3.000	.006	.033	3	3
COAD	INPP4B →	-0.434	-2.991	.025	.036	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 64 associations by consensus.

TFRC by ZNF638 expression — STAD

Explore this box plot interactively →