ZNF630-AS1

Across TCGA pan-cancer cohorts, ZNF630-AS1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated ZNF630-AS1 data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher ZNF630-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ZNF630-AS1 expression acts as an unfavorable survival marker, although some lineages such as BLCA and HNSC show a favorable association.

UVM, THYM, and BLCA are the cancer types where ZNF630-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	II,III,IV	0.228	0.670	<.001	51	view →
THYM	OS	Quartile	All	0.873	0.987	.001	41	view →
BLCA	OS	Tertile	All	0.805	0.666	.002	34	view →
DLBC	OS	Tertile	All	0.696	0.966	.009	31	view →
STAD	DFS	Median	III,IV	0.507	0.656	.007	25	view →
CHOL	OS	Median	IV	0.208	0.948	.010	15	view →
HNSC	DFS	Quartile	IV	0.822	0.488	.004	15	view →
TGCT	DFS	Tertile	All	0.507	0.800	.004	14	view →
ACC	DFS	Median	III,IV	0.617	0.273	.012	13	view →
MESO	DFS	Quartile	All	0.156	0.529	.020	12	view →
COAD	OS	Tertile	IV	0.307	0.632	.025	12	view →
READ	OS	Median	All	1.000	0.881	.022	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

ZNF630-AS1–UVM (DFS)

Open the UVM breakdown →