ZNF629

Across TCGA patient cohorts, ZNF629 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF629-associated genes across cancer lineages are mTOR_pS2448, ATM, and Cyclin-E2. Each is linked with ZNF629 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF629-to-partner and partner-to-ZNF629 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by ZNF629-low versus ZNF629-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF629→partner) and Y-score (partner→ZNF629) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.133	-2.439	.015	.019	3	3
UCEC	ATM →	-0.478	-2.247	.004	.001	3	3
UCEC	Cyclin-E2 →	+0.170	+1.817	.006	.015	3	3
UCEC	A-Raf_pS299 →	-0.191	-2.700	<.001	.006	3	2
UCEC	FoxM1 →	+0.225	+1.847	.018	.008	3	2
UCEC	FOXO3a_pS318_S321 →	-0.125	-1.502	.006	.030	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

mTOR_pS2448 by ZNF629 expression — UCEC

Explore this box plot interactively →