Across TCGA patient cohorts, ZNF627 mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF627-associated genes across cancer lineages are ATM, EGFR_pY1068, and JNK_pT183_Y185. Each is linked with ZNF627 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF627-to-partner and partner-to-ZNF627 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF627→partner) and Y-score (partner→ZNF627) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.480	-2.087	.005	.005	3	3
UCEC	EGFR_pY1068 →	-0.325	-2.584	<.001	.001	3	2
UCEC	JNK_pT183_Y185 →	-0.217	-2.807	<.001	.003	3	2
UCEC	Shc_pY317 →	-0.170	-3.169	.003	.018	3	2
UCEC	STAT3_pY705 →	-0.443	-2.222	<.001	.009	3	2
UCEC	C-Raf →	+0.190	+2.584	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

Exploration

ZNF627 survival (RNA) · tumor vs normal (RNA) · all ZNF627 data types