ZNF623

Across TCGA patient cohorts, ZNF623 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF623-associated genes across cancer lineages are ATM, EGFR_pY1068, and p38-MAPK_pT180_Y182. Each is linked with ZNF623 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF623-to-partner and partner-to-ZNF623 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by ZNF623-low versus ZNF623-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF623→partner) and Y-score (partner→ZNF623) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.414	-1.807	.002	<.001	3	3
UCEC	EGFR_pY1068 →	-0.207	-1.378	.005	.008	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.402	-1.365	.002	.008	3	2
UCEC	PDCD4 →	-0.558	-1.584	<.001	.002	3	2
UCEC	ASNS →	+0.362	+1.847	<.001	.007	3	2
COAD	Caspase-7-cleavedD198 →	+0.737	+2.467	.031	.011	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

ATM by ZNF623 expression — UCEC

Explore this box plot interactively →