ZNF623

Across TCGA cell cohorts, ZNF623 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ZNF623-associated genes across cancer lineages are SIGLEC5, RBMY1A1, and TBC1D21. Each is linked with ZNF623 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF623-to-partner and partner-to-ZNF623 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SIGLEC5 grouped by ZNF623-low versus ZNF623-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF623→partner) and Y-score (partner→ZNF623) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SIGLEC5 →	+0.022	+4.415	<.001	.007	3	1
SKIN	RBMY1A1 →	+0.491	+4.684	<.001	.002	3	1
LARGE_INTESTINE	TBC1D21 →	+0.010	+4.022	<.001	.006	3	1
LARGE_INTESTINE	XKR3 →	+0.043	+4.115	<.001	.001	3	1
LARGE_INTESTINE	VWC2L →	+0.009	+3.345	<.001	.007	3	1
LARGE_INTESTINE	KCNU1 →	+0.057	+3.345	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

SIGLEC5 by ZNF623 expression — SKIN

Explore this box plot interactively →