ZNF620

Across TCGA patient cohorts, ZNF620 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF620-associated genes across cancer lineages are Caspase-8, EGFR_pY1068, and ERK2. Each is linked with ZNF620 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF620-to-partner and partner-to-ZNF620 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-8 grouped by ZNF620-low versus ZNF620-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF620→partner) and Y-score (partner→ZNF620) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-8 →	-0.259	-3.432	.012	.005	3	2
UCEC	EGFR_pY1068 →	-0.308	-3.584	.002	.002	3	1
UCEC	ERK2 →	+0.194	+1.807	.014	.027	3	1
UCEC	JNK2 →	+0.212	+1.807	.009	.027	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.406	-1.794	.028	.027	3	1
UCEC	p62 Lck ligand →	+0.306	+3.331	.022	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Caspase-8 by ZNF620 expression — UCEC

Explore this box plot interactively →