ZNF619

Across TCGA patient cohorts, ZNF619 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF619-associated genes across cancer lineages are Ku80, p53, and 4E-BP1. Each is linked with ZNF619 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF619-to-partner and partner-to-ZNF619 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by ZNF619-low versus ZNF619-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF619→partner) and Y-score (partner→ZNF619) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.242	+1.676	.003	.007	3	2
UCEC	p53 →	-0.309	-1.662	.023	.011	3	2
UCEC	4E-BP1 →	+0.302	+2.145	.001	.009	3	2
UCEC	14-3-3_beta →	-0.118	-3.780	<.001	<.001	3	1
UCEC	EGFR_pY1068 →	-0.327	-2.392	<.001	<.001	3	1
UCEC	A-Raf_pS299 →	-0.133	-2.000	.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Ku80 by ZNF619 expression — UCEC

Explore this box plot interactively →