ZNF618

Across TCGA patient cohorts, ZNF618 mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF618-associated genes across cancer lineages are ATM, PCNA, and FoxM1. Each is linked with ZNF618 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZNF618-to-partner and partner-to-ZNF618 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by ZNF618-low versus ZNF618-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF618→partner) and Y-score (partner→ZNF618) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.546	-1.700	<.001	.001	3	4
UCEC	PCNA →	+0.216	+1.473	.001	.006	3	3
UCEC	FoxM1 →	+0.245	+2.222	.001	<.001	3	2
UCEC	HER3_pY1289 →	+0.067	+1.341	.011	.043	3	2
UCEC	INPP4B →	-0.286	-2.736	.003	<.001	3	2
UCEC	MEK1 →	+0.292	+1.999	.009	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

ATM by ZNF618 expression — UCEC

Explore this box plot interactively →