ZNF618

Across TCGA cell cohorts, ZNF618 mutation is significantly associated with the RNA expression of many other genes, with 1,036 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF618-associated genes across cancer lineages are MRM3, ZNF804B, and UNCX. Each is linked with ZNF618 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF618-to-partner and partner-to-ZNF618 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRM3 grouped by ZNF618-low versus ZNF618-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF618→partner) and Y-score (partner→ZNF618) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MRM3 →	+0.596	+2.364	.001	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	ZNF804B →	+0.053	+4.510	<.001	.003	3	3
PANCREAS	UNCX →	+0.027	+4.614	<.001	.004	3	2
KIDNEY	ADGRE3 →	+0.040	+5.000	<.001	.005	3	2
SKIN	ADH4 →	+0.093	+2.925	<.001	.007	3	2
LUNG_NSCLC_LUAD	OR2H1 →	+0.173	+3.866	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,036 associations by consensus.

MRM3 by ZNF618 expression — LARGE_INTESTINE

Explore this box plot interactively →