ZNF614

Across TCGA patient cohorts, ZNF614 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF614-associated genes across cancer lineages are TFRC, ASNS, and PCNA. Each is linked with ZNF614 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF614-to-partner and partner-to-ZNF614 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by ZNF614-low versus ZNF614-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF614→partner) and Y-score (partner→ZNF614) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TFRC →	+0.572	+3.025	.038	.019	3	2
COAD	ASNS →	+0.668	+3.008	.001	.019	3	2
UCEC	PCNA →	+0.237	+3.169	.006	.018	3	2
UCEC	S6_pS240_S244 →	+0.408	+2.321	.012	.034	3	2
COAD	PKC-a →	-0.306	-2.991	.036	.036	3	1
COAD	RAD51 →	+0.191	+3.008	.019	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

TFRC by ZNF614 expression — COAD

Explore this box plot interactively →