ZNF614

Across TCGA cell cohorts, ZNF614 mutation is significantly associated with the RNA expression of many other genes, with 37 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF614-associated genes across cancer lineages are MRO, FAM124A, and DLGAP1. Each is linked with ZNF614 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF614-to-partner and partner-to-ZNF614 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRO grouped by ZNF614-low versus ZNF614-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF614→partner) and Y-score (partner→ZNF614) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MRO →	+0.248	+3.392	<.001	.006	3	1
LARGE_INTESTINE	FAM124A →	+0.765	+3.295	<.001	.006	3	1
LARGE_INTESTINE	DLGAP1 →	+0.684	+3.215	<.001	.009	3	1
LARGE_INTESTINE	STOX2 →	+0.568	+3.064	.002	.009	3	1
LARGE_INTESTINE	C9orf153 →	+0.143	+3.497	.001	.004	3	1
LARGE_INTESTINE	DNAJA2 →	+0.512	+3.082	.003	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

MRO by ZNF614 expression — LARGE_INTESTINE

Explore this box plot interactively →